Using clozapine to reduce violence in people with schizophrenia
3/7 Clozapine for the Prevention of Violence in Schizophrenia: A Randomized Clinical Trial
['FUNDING_R01'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10873268
This study is looking at whether clozapine, a medication for schizophrenia, can help reduce violent behavior in people who are at high risk, and it will involve 280 participants over six months to see how well it works compared to regular treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10873268 on ClinicalTrials.gov |
What this research studies
This research investigates the effectiveness of clozapine, an antipsychotic medication, in reducing the risk of violent behavior among individuals with schizophrenia. The study will involve a randomized clinical trial with 280 participants who are at high risk for violence, comparing clozapine treatment to standard treatment. The trial will take place across seven sites, ensuring a diverse participant pool and robust data collection. Participants will be monitored over a 24-week period to assess changes in violent behavior.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with schizophrenia who are considered at high risk for violent behavior.
Not a fit: Patients with schizophrenia who are not at risk for violence or those who do not respond to clozapine may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment options for individuals with schizophrenia, potentially reducing violence and enhancing public safety.
How similar studies have performed: Previous studies have suggested that clozapine may be more effective than other antipsychotics in reducing aggression, but this trial aims to provide more definitive evidence in a community setting.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JARSKOG, LARS FREDRIK — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: JARSKOG, LARS FREDRIK
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.