Using chloroquine-based particles to treat inflammatory bowel disease
Chloroquine-based polymer particles as oral non-absorbable treatment of inflammatory bowel disease
This study is testing new oral beads made from chloroquine that aim to treat inflammation in the colon specifically for people with inflammatory bowel disease (IBD), helping to reduce side effects and improve their quality of life.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Nebraska Medical Center NIH-funded |
| Lab location | 1 site (Omaha, United States) |
| Project ID | NIH-10652269 on NIH RePORTER |
What this research studies
This research focuses on developing innovative oral beads made from chloroquine that target and treat inflammation in the colon for patients with inflammatory bowel disease (IBD). These beads are designed to remain in the colon and activate their therapeutic effects in response to inflammation, minimizing side effects typically associated with systemic medications. By using a localized treatment approach, the research aims to improve the quality of life for patients suffering from IBD. The project builds on recent advancements in material science to create a new type of anti-inflammatory treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with inflammatory bowel disease who experience chronic inflammation in the colon.
Not a fit: Patients with non-inflammatory bowel conditions or those who do not have a diagnosis of inflammatory bowel disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a safer and more effective treatment option for patients with inflammatory bowel disease.
How similar studies have performed: Other research has shown promise in using localized drug delivery systems for treating inflammatory conditions, suggesting potential success for this novel approach.
Where this research is happening
Omaha, United States
- University of Nebraska Medical Center — Omaha, United States (Active)
Researchers
- Principal investigator: Oupicky, David — University of Nebraska Medical Center
- Study coordinator: Oupicky, David
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.