Using chemicals and electricity to help DNA enter cells more effectively
Chemically Assisted Electrotransfer of DNA
['FUNDING_OTHER'] · DUKE UNIVERSITY · NIH-10909126
This study is looking at a new way to help DNA get into cells better, using a combination of electric pulses and special treatments, which could be really helpful for things like gene editing and vaccines, especially for diseases like COVID-19.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | DUKE UNIVERSITY (nih funded) |
| Locations | 1 site (DURHAM, UNITED STATES) |
| Trial ID | NIH-10909126 on ClinicalTrials.gov |
What this research studies
This research investigates how to improve the delivery of DNA into cells using a method called electrotransfer, which combines electric pulses with chemical treatments. The goal is to enhance the efficiency of this process for applications like genome editing and DNA vaccination, particularly in the context of diseases such as COVID-19. The study will explore the mechanisms of how DNA is transported within cells and how it can effectively enter the nucleus, which is crucial for successful treatment outcomes. By understanding these transport mechanisms, the research aims to develop better strategies for DNA delivery both in laboratory settings and potentially in living organisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who may benefit from advanced gene therapies or DNA vaccinations, particularly in relation to COVID-19.
Not a fit: Patients who do not have conditions requiring DNA delivery or those who are not eligible for gene therapy may not receive benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for various diseases by improving how DNA is delivered into cells.
How similar studies have performed: Previous research has shown promise in using electrotransfer for DNA delivery, indicating that this approach has potential for success.
Where this research is happening
DURHAM, UNITED STATES
- DUKE UNIVERSITY — DURHAM, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: YUAN, FAN — DUKE UNIVERSITY
- Study coordinator: YUAN, FAN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.