Using cerebrospinal fluid to improve diagnosis and treatment of brain tumors.
Official title: Integration of CSF Proteogenomics in the Diagnosis and Management of Diffuse Gliomas
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-10801783 · Data updated 2026-11-12
This study is looking at how we can use a sample of the fluid around your brain and spine to find special markers that help us better understand and treat aggressive brain tumors called diffuse gliomas, making it easier to track how well treatments are working.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | July 3, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $638,804 |
| NIH project number | 1R01CA279357-01A1 |
| Project ID | NIH-10801783 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with diffuse gliomas, particularly those undergoing treatment or monitoring for tumor recurrence.
✕Less likely to help
Patients with brain tumors other than diffuse gliomas or those who are not undergoing treatment may not benefit from this research.
What this research studies
This research focuses on improving the diagnosis and management of diffuse gliomas, which are common and aggressive brain tumors. It aims to utilize cerebrospinal fluid (CSF) to identify tumor-specific biomarkers, which can provide more accurate information about tumor recurrence and response to therapy. By analyzing the proteins present in CSF, the study seeks to overcome the limitations of current imaging techniques and invasive tissue sampling methods. The findings could lead to better-targeted treatments and monitoring strategies for patients with these tumors.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and personalized treatment plans for patients with diffuse gliomas.
How similar studies have gone: Previous research has shown promise in using liquid biopsies for other types of cancers, suggesting that this approach may also be effective for gliomas.
Where this research is happening
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Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Mansouri, Alireza — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Mansouri, Alireza
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.