Using cellular processes to treat atherosclerosis
Harnessing the Autophagy-Lysosomal Biogenesis Response in Macrophages to Treat Atherosclerosis
This study is looking at how improving the way certain immune cells in your body break down harmful substances can help treat atherosclerosis, which is a major cause of heart problems, and it aims to find new ways to support heart health for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-11098483 on NIH RePORTER |
What this research studies
This research investigates how enhancing the autophagy-lysosomal system in macrophages can help treat atherosclerosis, a major cause of cardiovascular diseases. The study focuses on understanding how nutrient signaling, particularly from amino acids and cholesterol, affects the ability of macrophages to degrade harmful substances in atherosclerotic plaques. By targeting specific pathways, the researchers aim to develop new therapeutic strategies that could improve heart health. Patients may benefit from insights gained through this research that could lead to innovative treatments for atherosclerosis.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals at risk for or diagnosed with atherosclerosis, particularly those with elevated cholesterol levels.
Not a fit: Patients who do not have atherosclerosis or related cardiovascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly reduce the progression of atherosclerosis and improve cardiovascular health.
How similar studies have performed: Previous research has shown promise in targeting similar cellular processes for treating atherosclerosis, indicating potential for success in this approach.
Where this research is happening
Pittsburgh, United States
- Veterans Health Administration — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Razani, Babak — Veterans Health Administration
- Study coordinator: Razani, Babak
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.