Using cell transformation to improve heart disease treatment
Official title: Harnessing endothelial cell transdifferentiation for cardiovascular therapy
Funded at Boise State University · NIH-10513527 · Data updated 2026-11-12
This study is looking at how certain cells in your blood vessels can turn into different types of cells to help treat heart problems, and it aims to find out if this change helps deliver important genetic material to heart cells, which could lead to new ways to improve heart health and repair damage.
Quick facts
| Grant type | R15 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boise State University NIH-funded |
| Lab location | 1 site (Boise, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2025 |
| Funding year | 2022 |
| Award (this year) | $408,731 |
| NIH project number | 1R15HL165397-01 |
| Project ID | NIH-10513527 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals suffering from cardiovascular diseases who may benefit from new treatment approaches.
✕Less likely to help
Patients with non-cardiovascular conditions or those who do not have any heart-related issues may not benefit from this research.
What this research studies
This research investigates how endothelial cells can change into other cell types to help treat cardiovascular diseases. The team will explore whether this transformation is responsible for delivering genetic material to heart cells through a viral vector. By using advanced techniques, they aim to understand the mechanisms behind this process and identify specific areas in the body where these changes occur. This could lead to new strategies for enhancing heart health and repairing damaged tissues.
Why it matters
Potential benefit: If successful, this research could lead to innovative therapies that improve heart function and recovery from cardiovascular diseases.
How similar studies have gone: While the approach of using cell transdifferentiation is gaining interest, this specific application in cardiovascular therapy is relatively novel and has not been extensively tested.
Where this research is happening
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Boise State University
Boise, United States Active
Researchers
- Principal investigator: Morrison, Brad — Boise State University
- Study coordinator: Morrison, Brad
Related research
Other NIH-funded projects on the same topics.
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Healthy Idaho Clinical & Translational Research Development Program
A multi-institution effort in Idaho to build clinical and translational research capacity and workforce to address local health needs.
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Healthy Idaho Health Research Core supports translational projects
A Boise State University program funds and guides health research projects in Idaho to turn ideas into bigger health improvements for local communities.
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Healthy Idaho Clinical and Translational Research Design and Data Management
A program to strengthen how clinical and translational studies are planned, run, and using health data across Idaho, helping researchers design better studies and use EHR data responsibly.
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Healthy Idaho community engagement for translational research
A Boise State University program aims to strengthen ties between researchers and Idaho communities to support research that meets local health needs.
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Healthy Idaho professional development for clinical and translational research
A program to help Idaho investigators build skills and mentoring networks to conduct high-quality clinical and translational research.
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Healthy Idaho Clinical & Translational Research Development Administrative Core
A funded administrative core in Idaho helps coordinate and support clinical and translational research to improve health across the state.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.