Using cell-free DNA to understand Alzheimer's disease progression
Cell-free DNA as a marker of progression in Alzheimer's dementia and its role in chronic inflammation
['FUNDING_R03'] · JOHNS HOPKINS UNIVERSITY · NIH-10725214
This study is looking at how a simple blood test that measures cell-free DNA can help identify people with mild cognitive impairment who might be at greater risk of developing Alzheimer's disease, so they can get help sooner.
Quick facts
| Phase | ['FUNDING_R03'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10725214 on ClinicalTrials.gov |
What this research studies
This research investigates how cell-free DNA (cf-DNA) can serve as a non-invasive marker to identify individuals with mild cognitive impairment (MCI) who are at higher risk of progressing to Alzheimer's disease (AD). By measuring cf-DNA levels in the blood, the study aims to uncover the relationship between cell death and chronic inflammation in the context of MCI and AD. The researchers will utilize digital PCR technology to analyze cf-DNA and its association with cognitive decline, potentially leading to earlier interventions for those at risk.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults aged 21 and older who have been diagnosed with mild cognitive impairment.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for early identification of individuals at risk for Alzheimer's disease, allowing for timely interventions.
How similar studies have performed: Previous research has shown promise in using biomarkers like cf-DNA to understand disease progression, indicating that this approach may yield valuable insights.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: NIDADAVOLU, LOLITA S — JOHNS HOPKINS UNIVERSITY
- Study coordinator: NIDADAVOLU, LOLITA S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.