Using cell cycle factors to help heart cells grow and repair after damage
Induction of Cardiomyocyte Proliferation via Transient Expression of Cell Cycle Factors as a Promising Therapy for Heart Failure
This study is exploring a new way to help people with heart failure by using special tools to encourage heart muscle cells to grow and repair themselves, aiming to improve heart function safely without increasing the risk of tumors.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baylor College of Medicine NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-10771242 on NIH RePORTER |
What this research studies
This research investigates a novel approach to treat heart failure by inducing the proliferation of heart muscle cells (cardiomyocytes) using a combination of four specific cell cycle regulators. The study utilizes adenoviral vectors to temporarily express these factors, which have shown promise in laboratory models for promoting cell division and improving heart function after damage. The goal is to enhance the regenerative capacity of cardiomyocytes while minimizing the risk of tumor formation. By focusing on transient expression, the researchers aim to make this therapy safer and more applicable for human patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults over 21 years old who have experienced heart damage, such as from a heart attack.
Not a fit: Patients with non-cardiac related conditions or those who do not have heart damage may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that significantly improve heart function and recovery for patients with heart failure.
How similar studies have performed: Other research has shown success in using cell cycle regulators for cell proliferation in laboratory settings, but this specific approach in humans is still being explored.
Where this research is happening
Houston, United States
- Baylor College of Medicine — Houston, United States (Active)
Researchers
- Principal investigator: Mohamed, Tamer M a — Baylor College of Medicine
- Study coordinator: Mohamed, Tamer M a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.