Using carbon monoxide biofoams to enhance cancer treatment for rectal cancer while protecting healthy tissue
Exploiting Carbon Monoxide Biofoams to Radio-Sensitize Rectal Cancer Cells While Protecting Normal Bowel
This study is exploring a new way to make radiation therapy work better for people with rectal cancer by using a special foam that delivers carbon monoxide, which may help target cancer cells more effectively while protecting healthy tissue.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Iowa NIH-funded |
| Lab location | 1 site (Iowa City, United States) |
| Project ID | NIH-11088838 on NIH RePORTER |
What this research studies
This research investigates the use of carbon monoxide biofoams as a novel approach to improve the effectiveness of radiation therapy in treating rectal cancer. By delivering carbon monoxide in a controlled manner, the study aims to sensitize cancer cells to radiation while minimizing damage to normal bowel tissue. The research focuses on understanding the biochemical mechanisms that allow carbon monoxide to selectively target cancer cells, potentially leading to better treatment outcomes and improved quality of life for patients. The study employs innovative methods for delivering carbon monoxide through the gastrointestinal tract, addressing previous challenges associated with its use.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with rectal cancer who are undergoing or are candidates for neoadjuvant chemoradiotherapy.
Not a fit: Patients with advanced rectal cancer who are not eligible for chemoradiotherapy or those with other significant health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for rectal cancer, reducing the need for surgical interventions and improving patients' quality of life.
How similar studies have performed: While the use of carbon monoxide in cancer treatment is a novel approach, preliminary studies have shown promise in similar applications, suggesting potential for success.
Where this research is happening
Iowa City, United States
- University of Iowa — Iowa City, United States (Active)
Researchers
- Principal investigator: Byrne, James Donald — University of Iowa
- Study coordinator: Byrne, James Donald
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.