Using CAR T cells to explore the connections between aging factors
Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of aging
This study is exploring how certain aging factors work together and how special immune cells called CAR T cells can help target and remove old, damaged cells, with the hope of finding new treatments for age-related diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project ID | NIH-11086695 on NIH RePORTER |
What this research studies
This research investigates how different factors related to aging interact with each other by utilizing CAR T cells, a type of immunotherapy. The approach focuses on understanding the hallmarks of aging, such as genomic instability and cellular senescence, and how they contribute to age-related diseases. By developing CAR T cells that can specifically target and eliminate senescent cells, the research aims to uncover the complex relationships among these aging factors. This could lead to new therapeutic strategies for age-associated conditions.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing age-related health issues or diseases associated with aging.
Not a fit: Patients who are not experiencing age-related conditions or are younger adults may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve health outcomes for aging individuals and those with age-related diseases.
How similar studies have performed: Previous research has shown promise in using CAR T cell therapy for targeting specific cell types, indicating potential success for this novel approach in aging.
Where this research is happening
Cold Spring Harbor, United States
- Cold Spring Harbor Laboratory — Cold Spring Harbor, United States (Active)
Researchers
- Principal investigator: Amor Vegas, Corina — Cold Spring Harbor Laboratory
- Study coordinator: Amor Vegas, Corina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.