Using CAR T cells to explore the connections between aging factors
Official title: Harnessing CAR T cells to deconstruct the interconnectivity among hallmarks of aging
Funded at Cold Spring Harbor Laboratory · NIH-11086695 · Data updated 2026-11-12
This study is exploring how certain aging factors work together and how special immune cells called CAR T cells can help target and remove old, damaged cells, with the hope of finding new treatments for age-related diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cold Spring Harbor Laboratory NIH-funded |
| Lab location | 1 site (Cold Spring Harbor, United States) |
| Project start | September 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $511,940 |
| NIH project number | 5R01AG082800-03 |
| Project ID | NIH-11086695 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing age-related health issues or diseases associated with aging.
✕Less likely to help
Patients who are not experiencing age-related conditions or are younger adults may not benefit from this research.
What this research studies
This research investigates how different factors related to aging interact with each other by utilizing CAR T cells, a type of immunotherapy. The approach focuses on understanding the hallmarks of aging, such as genomic instability and cellular senescence, and how they contribute to age-related diseases. By developing CAR T cells that can specifically target and eliminate senescent cells, the research aims to uncover the complex relationships among these aging factors. This could lead to new therapeutic strategies for age-associated conditions.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve health outcomes for aging individuals and those with age-related diseases.
How similar studies have gone: Previous research has shown promise in using CAR T cell therapy for targeting specific cell types, indicating potential success for this novel approach in aging.
Where this research is happening
-
Cold Spring Harbor Laboratory
Cold Spring Harbor, United States Active
Researchers
- Principal investigator: Amor Vegas, Corina — Cold Spring Harbor Laboratory
- Study coordinator: Amor Vegas, Corina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.