Using CAR T cell therapy to treat a type of brain tumor in children.
Defining a therapeutic platform for DIPG with mRNA CAR T cells and microglia inhibition
This study is exploring a new way to treat diffuse intrinsic pontine glioma (DIPG), a tough brain tumor in kids, by using a special therapy that helps the immune system fight cancer, and it's being led by Dr. Jessica Foster at the Children's Hospital of Philadelphia.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10902094 on NIH RePORTER |
What this research studies
This research focuses on developing a new treatment approach for diffuse intrinsic pontine glioma (DIPG), a challenging pediatric brain tumor. The project aims to utilize chimeric antigen receptor (CAR) T cell therapy, which harnesses the body's immune system to target and destroy cancer cells. The research involves advanced techniques such as single-cell RNA sequencing to better understand the tumor environment and improve treatment efficacy. The project is led by Dr. Jessica Foster at the Children's Hospital of Philadelphia, in collaboration with a team of experienced physician-scientists.
Who could benefit from this research
Good fit: Ideal candidates for this research are children diagnosed with diffuse intrinsic pontine glioma (DIPG) who are under 11 years old.
Not a fit: Patients with other types of brain tumors or those who are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a novel and effective treatment option for children suffering from DIPG, potentially improving survival rates and quality of life.
How similar studies have performed: Previous research has shown promise in using CAR T cell therapy for other types of cancers, indicating potential for success in this novel application for DIPG.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Foster, Jessica B — Children's Hosp of Philadelphia
- Study coordinator: Foster, Jessica B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.