Using cannabidiol to reduce brain inflammation related to chronic pain and depression
Evaluation of Cannabidiol for Reduction of Brain Neuroinflammation
This study is looking at whether CBD, a safe compound from cannabis, can help reduce inflammation in the brain that might be causing chronic low back pain and mild-to-moderate depression, so if you're dealing with these issues, your participation could help us learn more about a potential new treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11052520 on NIH RePORTER |
What this research studies
This research investigates the potential of cannabidiol (CBD), a non-intoxicating compound from cannabis, to alleviate neuroinflammation associated with chronic low back pain (cLBP) and mild-to-moderate depression. By examining the role of microglia and astrocytes in pain and depressive behaviors, the study aims to understand how CBD may reduce inflammation in the brain that contributes to these conditions. Patients will be monitored for changes in pain and depression symptoms as well as neuroinflammatory markers, providing insights into the effectiveness of CBD as a treatment option.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals experiencing chronic low back pain along with mild-to-moderate depressive symptoms.
Not a fit: Patients who do not have chronic low back pain or significant depressive symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new, safer treatment options for individuals suffering from chronic pain and depression.
How similar studies have performed: Previous studies have shown promising results for the use of CBD in reducing pain and depressive symptoms, indicating that this approach may be effective.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Loggia, Marco Luciano — Massachusetts General Hospital
- Study coordinator: Loggia, Marco Luciano
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.