Using bupropion to help new mothers avoid smoking relapse after childbirth
Official title: Bupropion for the prevention of postpartum smoking relapse
Funded at University of Minnesota · NIH-10889091 · Data updated 2026-11-12
This study is looking at how well bupropion can help women who quit smoking during pregnancy stay smoke-free after having their baby, especially during the tough postpartum period when many might start smoking again.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | September 30, 2019 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $560,168 |
| NIH project number | 5R01DA047287-05 |
| Project ID | NIH-10889091 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women who have successfully quit smoking during pregnancy and are at risk of relapse postpartum.
✕Less likely to help
Patients who have never smoked or those who did not quit smoking during pregnancy may not benefit from this research.
What this research studies
This research investigates the effectiveness of bupropion, a medication commonly used for smoking cessation, in preventing relapse among women who quit smoking during pregnancy. The study focuses on the postpartum period, which is a critical time when many women return to smoking. By addressing factors such as depression and weight concerns that contribute to relapse, the research aims to provide a comprehensive treatment approach. Participants will receive bupropion and be monitored for their smoking habits and overall well-being.
Why it matters
Potential benefit: If successful, this research could significantly reduce smoking relapse rates among new mothers, leading to better health outcomes for both mothers and their children.
How similar studies have gone: Previous research has shown that bupropion can effectively aid smoking cessation in the general population, suggesting potential for success in this specific postpartum context.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Allen, Sharon S — University of Minnesota
- Study coordinator: Allen, Sharon S
Related research
Other NIH-funded projects on the same topics.
-
Promoting Breastfeeding to Prevent Postpartum Smoking Relapse
A trial tests whether encouraging new mothers to breastfeed helps prevent them from starting to smoke again after giving birth.
-
Helping new mothers avoid smoking after childbirth
This project looks at whether adjusting hormone levels can help new mothers stay smoke-free after their baby is born, protecting both mom and child.
-
Using hormone therapy to help new mothers avoid smoking relapse
This study is looking at how giving new moms a hormone called progesterone might help them avoid smoking again after having a baby, making it easier for them to stay smoke-free and protect their little ones from secondhand smoke.
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Social stress and smoking: why disadvantaged young adults struggle to quit
This grant looks at how daily social stress affects if and when disadvantaged young adults who smoke can quit and stay quit.
-
Adaptive treatment for early smoking relapse in adults
This study tests different paths to help adults who smoke quit again after an early relapse, including trying a different quitting medicine or switching to a safer nicotine product.
-
CBT for Insomnia to Help Adults Who Smoke Quit and Sleep Better
A sleep-focused therapy is tested to help adults who smoke sleep better, feel less negative, and improve their ability to quit smoking.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.