Using bulgecins to enhance the effectiveness of beta-lactam antibiotics against resistant bacteria
Bulgecin Template for Potentiation of beta-Lactam Antibiotics
This study is looking at how natural compounds called bulgecins can help make certain antibiotics work better against tough bacterial infections, especially for people dealing with antibiotic-resistant bacteria.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Notre Dame NIH-funded |
| Lab location | 1 site (Notre Dame, United States) |
| Project ID | NIH-10861928 on NIH RePORTER |
What this research studies
This research investigates the use of bulgecins, natural compounds that can enhance the effectiveness of beta-lactam antibiotics, specifically against Gram-negative bacterial infections. The researchers are exploring how bulgecins interact with bacterial cell structures to create vulnerabilities that allow antibiotics to work more effectively. Through laboratory experiments, they are documenting the effects of these compounds on bacteria and identifying the specific targets within the bacterial cells. This approach aims to provide a new strategy for treating infections caused by antibiotic-resistant bacteria.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by Gram-negative bacteria that are resistant to standard antibiotic treatments.
Not a fit: Patients with infections caused by Gram-positive bacteria or those who do not have antibiotic-resistant infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for infections caused by resistant Gram-negative bacteria, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using natural compounds to enhance antibiotic effectiveness, suggesting that this approach could yield significant results.
Where this research is happening
Notre Dame, United States
- University of Notre Dame — Notre Dame, United States (Active)
Researchers
- Principal investigator: Mobashery, Shahriar — University of Notre Dame
- Study coordinator: Mobashery, Shahriar
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.