Using brain stimulation to improve cognitive functions in Alzheimer's disease
Transcranial direct current stimulation in typical and atypical Alzheimer's disease
This study is looking at how a gentle brain stimulation technique, combined with language and memory exercises, can help improve thinking skills in people with Alzheimer's disease, by comparing real treatment to a placebo.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10897991 on NIH RePORTER |
What this research studies
This research investigates the effects of Transcranial Direct Current Stimulation (tDCS) on cognitive decline in patients with Alzheimer's disease. It employs a non-invasive method to stimulate specific brain areas while integrating behavioral therapy focused on language, learning, and memory. The study aims to compare the effects of active tDCS versus a sham treatment to assess improvements in cognitive functions, particularly in language and memory. By targeting the left angular gyrus, the research seeks to enhance brain connectivity and mitigate synaptic damage associated with Alzheimer's.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with typical or atypical Alzheimer's disease who are experiencing cognitive decline.
Not a fit: Patients with advanced Alzheimer's disease or those who do not have a diagnosis of Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved cognitive functions and quality of life for patients with Alzheimer's disease.
How similar studies have performed: Previous studies have shown promising results with tDCS in enhancing cognitive functions in neurodegenerative disorders, indicating potential for success in this research.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Tsapkini, Kyrana — Johns Hopkins University
- Study coordinator: Tsapkini, Kyrana
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.