Using brain stimulation to improve blood flow and metabolism in Alzheimer's disease models
Extracranial Brain Stimulation Reduces Metabolic Insufficiency Through Enhanced Cerebral Blood Flow in CVN-AD Alzheimer's Model
This study is looking at whether a special type of electrical stimulation can help improve blood flow and brain function in animals with Alzheimer's disease, which might lead to new ways to treat the condition and slow its progression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Duke University NIH-funded |
| Lab location | 1 site (Durham, United States) |
| Project ID | NIH-11014363 on NIH RePORTER |
What this research studies
This research investigates how transcranial alternating current electrical stimulation (tACS) can enhance cerebral blood flow and metabolic function in an animal model of Alzheimer's disease. By applying electrical stimulation through electrodes mounted on the skull, the study aims to determine the optimal frequencies for improving brain health and potentially slowing disease progression. The research will also assess behavioral outcomes and physiological markers to evaluate the effectiveness of the stimulation over a four-week period. This approach could lead to new insights into treating Alzheimer's disease by addressing metabolic insufficiencies in the brain.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk of developing it, particularly older adults.
Not a fit: Patients with non-Alzheimer's forms of dementia or those with severe cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to innovative treatments that improve brain metabolism and function in patients with Alzheimer's disease.
How similar studies have performed: Previous research has shown promise in using electrical stimulation techniques for neurological conditions, suggesting potential for success in this novel application.
Where this research is happening
Durham, United States
- Duke University — Durham, United States (Active)
Researchers
- Principal investigator: Turner, Dennis Alan — Duke University
- Study coordinator: Turner, Dennis Alan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.