Using brain-derived exosomes to identify cognitive impairment in HIV patients
Plasma neuronal-derived exosomes are biomarkers of HIV cognitive impairment
This study is looking at tiny particles in the blood of people with chronic HIV to see if they can help spot problems with thinking and memory, which can sometimes happen with HIV, and it hopes to find easier and cheaper ways to diagnose these issues compared to regular brain scans.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10813849 on NIH RePORTER |
What this research studies
This research investigates the role of neuron-derived exosomes in the blood of individuals with chronic HIV infection to identify cognitive impairment. By isolating these exosomes and analyzing their protein content, the study aims to find reliable biomarkers that can indicate cognitive decline associated with HIV. The approach utilizes advanced techniques like mass spectroscopy and proximity extension analysis to differentiate between cognitive impairment in HIV patients and conditions like Alzheimer's disease. This could lead to more accessible and cost-effective diagnostic methods compared to traditional neuroimaging.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with chronic HIV infection who are experiencing cognitive difficulties.
Not a fit: Patients who do not have HIV or those without cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could provide a non-invasive and cost-effective way to diagnose cognitive impairment in HIV patients, leading to better management and treatment strategies.
How similar studies have performed: Previous research has shown promise in using exosomes as biomarkers for various conditions, suggesting potential success for this novel approach in HIV-related cognitive impairment.
Where this research is happening
San Francisco, United States
- Northern California Institute/res/edu — San Francisco, United States (Active)
Researchers
- Principal investigator: Pulliam, Lynn — Northern California Institute/res/edu
- Study coordinator: Pulliam, Lynn
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.