Using brain-derived circRNAs to improve stroke diagnosis through blood tests
Investigation of brain-originating circRNAs as targets in blood-based stroke triage diagnostics
['FUNDING_R01'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11040353
This study is looking to create a new blood test that can help doctors quickly and accurately detect strokes by checking for special molecules from the brain, which could lead to faster treatment and better recovery for patients.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11040353 on ClinicalTrials.gov |
What this research studies
This research aims to develop a new blood-based diagnostic tool for stroke by investigating circular RNAs (circRNAs) that originate from the brain. Current methods for identifying strokes rely heavily on symptoms, which can often lead to misdiagnosis. By focusing on circRNAs, which are stable and accumulate in neurons, the study seeks to create a more reliable biomarker for early detection of strokes in emergency settings. This could lead to faster treatment and better outcomes for patients experiencing a stroke.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who are suspected of having a stroke or are experiencing stroke-like symptoms.
Not a fit: Patients who have already been diagnosed with a stroke and are receiving treatment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the accuracy of stroke diagnosis, leading to timely interventions and better recovery outcomes for patients.
How similar studies have performed: Previous research has shown promise in using biomarkers for stroke detection, but this approach focusing on circRNAs is relatively novel and untested.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: O'CONNELL, GRANT C — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: O'CONNELL, GRANT C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Acquired brain injury