Using brain and computational tools to understand opioid use disorder and its effects on decision-making.
Official title: Integrating brain, neurocognitive, and computational tools in Opioid Use Disorder (OUD) to characterize executive function and to predict clinical outcomes
Funded at University of Pennsylvania · NIH-11031951 · Data updated 2026-11-12
This study is looking at how opioid use disorder affects thinking skills and recovery by using brain scans and tests, with the hope of finding better ways to help people with this condition and prevent them from relapsing.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | March 1, 2023 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $189,646 |
| NIH project number | 5K01DA056700-03 |
| Project ID | NIH-11031951 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with opioid use disorder, particularly those experiencing co-occurring mental health issues.
✕Less likely to help
Patients who do not have opioid use disorder or related cognitive impairments may not benefit from this research.
What this research studies
This research investigates how opioid use disorder (OUD) affects executive function and clinical outcomes by integrating brain imaging, neurocognitive assessments, and advanced computational methods like deep learning. The goal is to identify the impact of OUD and related issues, such as anxiety and depression, on cognitive abilities and treatment success. By understanding these relationships, the research aims to improve treatment strategies and prevent relapse in individuals struggling with OUD. Patients may be assessed through various cognitive tests and brain imaging techniques to gather data on their condition.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatment strategies for individuals with opioid use disorder, improving their chances of recovery.
How similar studies have gone: Previous research has shown promise in using neurocognitive and imaging tools to understand addiction, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Pennsylvania
Philadelphia, United States Active
Researchers
- Principal investigator: Regier, Paul — University of Pennsylvania
- Study coordinator: Regier, Paul
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.