Using botanicals to improve brain health and resilience in older adults

Botanicals enhancing neurological and functional resilience in aging (BENFRA)

NIH-funded research Oregon Health & Science University · NIH-10875566

This study is looking at how two natural supplements, Centella asiatica and Withania somnifera, might help older adults feel better, sleep well, and think more clearly, with the hope of improving their overall quality of life.

Quick facts

Grant typeNIH-funded research
Study typeNIH-funded research
Funding institutionOregon Health & Science University NIH-funded
Lab location1 site (Portland, United States)
Project IDNIH-10875566 on NIH RePORTER

What this research studies

This research investigates how certain botanical dietary supplements, specifically Centella asiatica and Withania somnifera, can enhance neurological and functional resilience in aging individuals. The study aims to evaluate the effectiveness of these botanicals in improving mood, sleep, and cognitive function through well-designed clinical trials. Researchers will explore the active components of these botanicals, their mechanisms of action, and how they interact within the body. The goal is to establish a solid foundation for future clinical trials that could lead to improved quality of life for older adults.

Who could benefit from this research

Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or related mood and sleep disturbances.

Not a fit: Patients who are not elderly or do not experience any cognitive or mood-related issues may not benefit from this research.

Why it matters

Potential benefit: If successful, this research could provide older adults with effective natural options to enhance cognitive function and overall well-being.

How similar studies have performed: Previous research has shown promising results with botanical supplements in improving cognitive function, suggesting potential for success in this area.

Where this research is happening

Portland, United States

Researchers

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions Alzheimer disease dementiaAlzheimer syndromeAlzheimer's Disease
Last reviewed 2026-06-13 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.