Using bone marrow transplantation to treat various diseases
Bone Marrow Transplantation in Human Disease
['FUNDING_P01'] · JOHNS HOPKINS UNIVERSITY · NIH-10907578
This study is looking at how a treatment called post-transplant cyclophosphamide can help make bone marrow transplants safer and easier for patients, especially older ones, by reducing complications and improving the chances of staying cancer-free after the transplant.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | JOHNS HOPKINS UNIVERSITY (nih funded) |
| Locations | 1 site (BALTIMORE, UNITED STATES) |
| Trial ID | NIH-10907578 on ClinicalTrials.gov |
What this research studies
This research investigates the use of post-transplant cyclophosphamide (PTCy) to improve outcomes for patients undergoing bone marrow transplantation (BMT). It focuses on making haploidentical BMT safer and more accessible, even for older patients, by reducing complications like graft-versus-host disease (GVHD). The study aims to explore maintenance therapies after BMT to further decrease the risk of cancer relapse, leveraging the enhanced immune response from the transplant. By utilizing both matched and mismatched donors, the research seeks to broaden the availability of BMT for patients in need.
Who could benefit from this research
Good fit: Ideal candidates for this research include patients with conditions such as acute myeloid leukemia or AIDS-related malignancies who require bone marrow transplantation.
Not a fit: Patients who are not candidates for bone marrow transplantation or those with conditions not addressed by this research may not benefit.
Why it matters
Potential benefit: If successful, this research could significantly improve survival rates and quality of life for patients undergoing bone marrow transplantation.
How similar studies have performed: Previous research has shown promising results with similar approaches, particularly in improving outcomes for patients receiving haploidentical BMT.
Where this research is happening
BALTIMORE, UNITED STATES
- JOHNS HOPKINS UNIVERSITY — BALTIMORE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: JONES, RICHARD J — JOHNS HOPKINS UNIVERSITY
- Study coordinator: JONES, RICHARD J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: AIDS associated cancer, AIDS related cancer, Acquired Immune Deficiency Syndrome Virus, Acquired Immunodeficiency Syndrome Virus