Using bone marrow concentrate to treat osteonecrosis of the femoral head
Official title: Autologous Bone Marrow Aspirate Concentrate for the Treatment of Osteonecrosis of the Femoral Head
Funded at Johns Hopkins University · NIH-10904704 · Data updated 2026-11-12
This study is looking at whether using your own bone marrow during surgery can help improve recovery for people with early-stage osteonecrosis of the femoral head, and it aims to see if this combination leads to less pain and better joint health over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | August 10, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $822,027 |
| NIH project number | 5U01AR080993-02 |
| Project ID | NIH-10904704 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with early-stage osteonecrosis of the femoral head who are experiencing joint pain but have not yet reached the end-stage of the disease.
✕Less likely to help
Patients with advanced osteonecrosis requiring total hip replacement or those with contraindications for surgery may not benefit from this research.
What this research studies
This research investigates the use of autologous bone marrow aspirate concentrate (BMAC) to enhance the effectiveness of core decompression surgery for patients with early-stage osteonecrosis of the femoral head (ONFH). The study aims to determine if combining BMAC with the standard surgical procedure can lead to improved clinical and radiological outcomes. By conducting a randomized controlled trial, the researchers will gather robust data on the efficacy of this treatment approach. Patients will be monitored for pain relief and joint preservation over time.
Why it matters
Potential benefit: If successful, this research could provide a new treatment option that improves outcomes for patients suffering from early-stage osteonecrosis of the femoral head.
How similar studies have gone: Previous studies have shown promise in using bone marrow aspirate concentrate for various orthopedic conditions, but this specific approach for ONFH is still being rigorously tested.
Where this research is happening
-
Johns Hopkins University
Baltimore, United States Active
Researchers
- Principal investigator: Jones, Lynne C. — Johns Hopkins University
- Study coordinator: Jones, Lynne C.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.