Using blood thinners to prevent strokes in patients who survived brain hemorrhages
Anticoagulation in ICH Survivors for Prevention and Recovery (ASPIRE)
This study is looking at whether blood-thinning medications can help people with a history of brain bleeding and a heart condition called atrial fibrillation lower their chances of having a stroke, without causing more bleeding in the brain.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10829461 on NIH RePORTER |
What this research studies
This research investigates the use of anticoagulant therapy in patients with a history of intracerebral hemorrhage who also have atrial fibrillation, a common heart-rhythm disorder. The study aims to determine whether anticoagulants can safely reduce the risk of ischemic strokes without increasing the risk of recurrent hemorrhagic strokes. By conducting randomized, blinded clinical trials, the research seeks to provide high-quality evidence on the effectiveness and safety of anticoagulation in this patient population. Participants will be monitored for long-term functional outcomes and overall mortality rates.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with a history of intracerebral hemorrhage and atrial fibrillation.
Not a fit: Patients who do not have a history of intracerebral hemorrhage or those without atrial fibrillation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of strokes and improve survival rates for patients with atrial fibrillation who have previously experienced a brain hemorrhage.
How similar studies have performed: Preliminary data from multicenter studies suggest that anticoagulation may be beneficial for this patient group, indicating a promising avenue for further investigation.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Sheth, Kevin Navin — Yale University
- Study coordinator: Sheth, Kevin Navin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.