Using blood tests to track sepsis through cell-free DNA analysis
Official title: Liquid biopsy cell-free DNA analysis to monitor sepsis
Funded at Medical College of Wisconsin · NIH-10887149 · Data updated 2026-11-12
This study is looking at how cell-free DNA in your blood could help doctors spot sepsis earlier, which could lead to better treatment and outcomes for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical College of Wisconsin NIH-funded |
| Lab location | 1 site (Milwaukee, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $166,204 |
| NIH project number | 1K08GM150038-01A1 |
| Project ID | NIH-10887149 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals who are at risk of developing sepsis or are currently experiencing symptoms of this condition.
✕Less likely to help
Patients who do not have sepsis or are not at risk for this condition may not receive any benefit from this research.
What this research studies
This research investigates the use of cell-free DNA found in blood samples as a new biomarker to monitor sepsis, a life-threatening condition. The principal investigator, Dr. Nicholas P. Semenkovich, aims to develop advanced techniques and algorithms to analyze this DNA, which could lead to earlier detection and better management of sepsis. The study will involve collaboration with experts in sepsis and critical care to ensure comprehensive insights and guidance throughout the research process. Patients may benefit from improved diagnostic methods that could enhance treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to more effective monitoring and treatment of sepsis, potentially saving lives.
How similar studies have gone: Previous research has shown promise in using cell-free DNA as biomarkers in various conditions, suggesting potential success for this novel approach in sepsis.
Where this research is happening
-
Medical College of Wisconsin
Milwaukee, United States Active
Researchers
- Principal investigator: Semenkovich, Nicholas P — Medical College of Wisconsin
- Study coordinator: Semenkovich, Nicholas P
Related research
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.