Using blood tests to predict side effects and benefits of pembrolizumab in early stage triple negative breast cancer

Who could benefit from this research

What this research studies

This research investigates how specific blood markers can help predict which patients with early stage triple negative breast cancer will experience adverse effects or benefit from treatment with pembrolizumab, an immune checkpoint inhibitor. By analyzing over 3,000 serum samples from nearly 1,200 patients, the study aims to identify auto-antibodies that could serve as reliable predictors of treatment outcomes. The approach focuses on utilizing easily accessible blood samples to measure immune responses, potentially leading to better personalized treatment strategies. Collaboration among experts in immunoproteomics and breast cancer will enhance the study's effectiveness.

Why it matters

Where this research is happening

• Arizona State University-Tempe Campus
  Tempe, United States Active

Researchers

• Principal investigator: Qiu, Ji — Arizona State University-Tempe Campus
• Study coordinator: Qiu, Ji

Related research

Other NIH-funded projects on the same topics.

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• Dormancy in Triple-Negative Breast Cancer: How Liver and Skin Metastases Go Quiet or Reactivate

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  NIH research Massachusetts Institute of Technology · Cambridge, United States · NIH-11531542

• Rac-enhanced CAR-Macrophages against TNBC

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  NIH research University of Louisville · Louisville, United States · NIH-11520503

• A new peptide therapy to help treat metastatic triple-negative breast cancer

  A new peptide therapy called PEG-FUD is being tested to help treat metastatic triple-negative breast cancer by normalizing the tumor environment to improve treatment delivery.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11453153

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.