Using blood tests to identify atypical Alzheimer's disease
Official title: Blood plasma metrics as disease biomarkers in atypical Alzheimer's disease
Funded at Mayo Clinic Rochester · NIH-11033057 · Data updated 2026-11-12
This study is looking at blood tests to see if they can help doctors better diagnose atypical Alzheimer's disease, which affects some people who show different symptoms, and it's for anyone who might be experiencing these unusual signs or has loved ones who are.
Quick facts
| Grant type | R03 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2026 |
| Funding year | 2025 |
| Award (this year) | $320,143 |
| NIH project number | 1R03AG091264-01 |
| Project ID | NIH-11033057 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals exhibiting atypical symptoms of Alzheimer's disease, such as visual, language, or behavioral difficulties.
✕Less likely to help
Patients who do not exhibit atypical symptoms or those diagnosed with other forms of dementia may not benefit from this research.
What this research studies
This research investigates the potential of blood plasma biomarkers to improve the diagnosis of atypical Alzheimer's disease, which affects about 25% of patients presenting with non-amnestic symptoms. By analyzing existing blood samples and clinical data from a cohort of 210 patients, the study aims to determine how well these biomarkers can differentiate atypical Alzheimer's patients from healthy individuals and those with similar symptoms but without Alzheimer's. The goal is to enhance diagnostic accuracy and reduce delays in identifying the disease, ultimately aiding in better patient management and treatment planning.
Why it matters
Potential benefit: If successful, this research could lead to more accurate and timely diagnoses for patients with atypical Alzheimer's disease.
How similar studies have gone: Previous research has shown promise in using blood biomarkers for diagnosing various forms of Alzheimer's disease, suggesting potential success for this approach in atypical cases.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Singh-Reilly, Neha — Mayo Clinic Rochester
- Study coordinator: Singh-Reilly, Neha
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.