Using blood tests to detect liver cancer in patients with hepatitis B in Nigeria.
Official title: Use of Peripheral Blood Mononuclear Cells Mitochondrial DNA Content to Detect Hepatocellular Carcinoma in Hepatitis B Virus Infected Nigerians.
Funded at College of Medicine, University of Lagos · NIH-11072018 · Data updated 2026-11-12
This study is looking to create a simple blood test that can help find liver cancer in people with chronic hepatitis B by checking the levels of certain DNA in their immune cells, and it's for patients visiting gastroenterology clinics in Lagos, Nigeria.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | College of Medicine, University of Lagos NIH-funded |
| Lab location | 1 site (Lagos, Nigeria) |
| Project start | July 27, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $120,608 |
| NIH project number | 5K43TW012589-03 |
| Project ID | NIH-11072018 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic hepatitis B and those with hepatocellular carcinoma.
✕Less likely to help
Patients without hepatitis B virus infection or liver cancer are unlikely to benefit from this research.
What this research studies
This research focuses on developing a blood test that measures mitochondrial DNA content in immune cells to detect liver cancer in patients infected with hepatitis B virus (HBV). The study aims to enroll patients with chronic hepatitis B and liver cancer at gastroenterology clinics in Lagos, Nigeria. By comparing the mitochondrial DNA levels in these patients to those without the infection or cancer, the researchers hope to improve diagnostic accuracy. This minimally invasive approach could provide a more effective way to identify liver cancer early.
Why it matters
Potential benefit: If successful, this research could lead to a more accurate and less invasive method for diagnosing liver cancer in hepatitis B patients.
How similar studies have gone: Similar research has shown promise in using mitochondrial DNA as a biomarker for cancer detection, suggesting potential success for this approach.
Where this research is happening
-
College of Medicine, University of Lagos
Lagos, Nigeria Active
Researchers
- Principal investigator: Adisa, Rahmat Adetutu — College of Medicine, University of Lagos
- Study coordinator: Adisa, Rahmat Adetutu
Related research
Other NIH-funded projects on the same topics.
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Blood markers to catch early liver cancer in Hispanic people with hepatitis B
This project will see if a blood test can find liver cancer earlier in Hispanic people who have chronic hepatitis B.
-
Early blood markers to find hepatitis B–related liver cancer in Hispanics
This project will use immune-related blood markers to find liver cancer earlier in people with chronic hepatitis B, focusing on Hispanic adults.
-
HBV integrations in KMT2B may drive liver cancer
Aims to understand how hepatitis B can cause liver cancer by studying HBV inserts in the KMT2B gene and how these changes affect liver cells.
-
Blood test to detect early liver cancer in Hispanic people with hepatitis B
This project looks at whether a blood-based panel of immune markers can find early liver cancer in Hispanic adults who have chronic hepatitis B.
-
Understanding how Hepatitis B causes liver cancer
This research explores how the Hepatitis B virus changes a specific gene to cause liver cancer, hoping to find new ways to help patients.
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Finding blood markers to detect liver cancer early in Hispanic patients with hepatitis B.
This study is looking for blood tests that can help predict if people with hepatitis B, especially those in the Hispanic community, might develop liver cancer early on, making it easier to catch and treat the disease before it gets serious.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.