Using blood samples to find biomarkers for Alzheimer's disease
MicroRNAs in CNS-derived extracellular microvesicles as peripheral blood biomarkers for Alzheimer disease
['FUNDING_R01'] · UNIVERSITY OF WASHINGTON · NIH-10682404
This study is looking for tiny molecules in your blood that could help doctors spot Alzheimer's disease earlier and more easily, so you won't have to rely on expensive scans or uncomfortable tests.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF WASHINGTON (nih funded) |
| Locations | 1 site (SEATTLE, UNITED STATES) |
| Trial ID | NIH-10682404 on ClinicalTrials.gov |
What this research studies
This research focuses on identifying microRNAs in extracellular microvesicles derived from the central nervous system that can serve as biomarkers for Alzheimer's disease. By analyzing blood plasma, the study aims to overcome challenges associated with current diagnostic methods, such as the high costs of neuroimaging and the invasiveness of cerebrospinal fluid sampling. The approach utilizes established techniques like RT-PCR to measure microRNAs, which are crucial for regulating protein levels in cells. The goal is to improve the sensitivity and specificity of blood-based biomarkers, potentially allowing for earlier detection of Alzheimer's disease and mild cognitive impairment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals showing early signs of cognitive decline or those at risk for Alzheimer's disease.
Not a fit: Patients with advanced Alzheimer's disease or those without any cognitive impairment may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accessible and less invasive methods for diagnosing Alzheimer's disease at earlier stages.
How similar studies have performed: Previous research has shown promise in using microRNAs as biomarkers for various diseases, indicating potential success for this novel approach in Alzheimer's disease.
Where this research is happening
SEATTLE, UNITED STATES
- UNIVERSITY OF WASHINGTON — SEATTLE, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SHI, MIN — UNIVERSITY OF WASHINGTON
- Study coordinator: SHI, MIN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease