Using blood DNA changes to improve colorectal cancer prevention
Harnessing DNA methylation in peripheral blood for improved colorectal cancer prevention
This study is looking at how changes in DNA from blood samples can help spot people at risk for colorectal cancer before they have any symptoms, with the hope of finding ways to catch it early and prevent it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10978829 on NIH RePORTER |
What this research studies
This research investigates how changes in DNA methylation in blood samples can help identify individuals at risk for colorectal cancer (CRC) before symptoms appear. By analyzing blood from a large group of participants over many years, the study aims to uncover specific DNA markers that indicate CRC risk and how lifestyle factors may influence these changes. The goal is to develop a method for early detection and prevention of CRC, potentially allowing for interventions before cancer develops.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who are at risk for colorectal cancer, particularly those with a family history or lifestyle factors that may contribute to the disease.
Not a fit: Patients who have already been diagnosed with colorectal cancer or those with no risk factors for the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for early detection and prevention of colorectal cancer, improving patient outcomes.
How similar studies have performed: Previous research has shown promise in using DNA methylation markers for cancer detection, suggesting that this approach could be effective.
Where this research is happening
Boston, United States
- Harvard School of Public Health — Boston, United States (Active)
Researchers
- Principal investigator: Song, Mingyang — Harvard School of Public Health
- Study coordinator: Song, Mingyang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.