Using blood and urine biomarkers to find and guide treatment of kidney problems in people with HIV
Biomarker-Based Diagnostic Algorithms To Prevent, Detect And Guide Treatment Of Kidney Disease In Persons Living With HIV
This project uses specific blood and urine biomarkers to find, monitor, and guide treatment of kidney problems in people living with HIV.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northern California Institute/res/edu NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-10915408 on NIH RePORTER |
What this research studies
Right now, doctors mainly use blood creatinine and urine protein to check kidney health, which can miss early problems. This project combines newer 'tubule' biomarkers from blood and urine with diagnostic algorithms to find kidney injury earlier in people living with HIV. The team will follow patients, collect samples, and apply computational models to create tools that tell clinicians when to start or change treatments. The goal is to move these biomarker-based tools into routine clinic use so kidney disease can be caught and managed sooner.
Who could benefit from this research
Good fit: Adults living with HIV who receive clinical care and may be at risk for kidney problems—for example those on antiretroviral therapy or with diabetes or high blood pressure—would be ideal candidates.
Not a fit: People without HIV, children, or those already on dialysis for end-stage kidney disease are unlikely to benefit from this work.
Why it matters
Potential benefit: If successful, this could detect kidney disease earlier and help clinicians personalize care to prevent progression in people with HIV.
How similar studies have performed: Previous work, including studies by this team, showed that tubule biomarkers give more diagnostic and prognostic information than conventional tests, but applying these biomarker algorithms in routine care is still new.
Where this research is happening
San Francisco, United States
- Northern California Institute/res/edu — San Francisco, United States (Active)
Researchers
- Principal investigator: Shlipak, Michael G — Northern California Institute/res/edu
- Study coordinator: Shlipak, Michael G
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.