Using bisphosphonates to prevent bone loss after weight loss surgery
Bisphosphonate Use to Mitigate Bone Loss Secondary to Bariatric Surgery
This study is looking at whether a monthly medication called risedronate can help people who have had sleeve gastrectomy surgery keep their bones strong and reduce the risk of fractures as they lose weight.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Wake Forest University NIH-funded |
| Lab location | 1 site (Winston-Salem, United States) |
| Project ID | NIH-10832532 on NIH RePORTER |
What this research studies
This research investigates the use of a medication called risedronate, a type of bisphosphonate, to help prevent bone loss in patients who have undergone sleeve gastrectomy (SG) for weight loss. The study aims to determine if risedronate can reduce the risk of fractures by inhibiting bone resorption, which tends to increase after SG. Patients will receive this medication once a month, and the research will assess its effectiveness in preserving bone density and potentially lean muscle mass over time. The findings could lead to improved management strategies for patients recovering from bariatric surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have undergone sleeve gastrectomy and are at risk for bone loss.
Not a fit: Patients who have not had bariatric surgery or those with pre-existing severe bone conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly reduce the risk of bone fractures in patients who have had bariatric surgery.
How similar studies have performed: Previous studies have shown promising results with bisphosphonates in reducing bone loss, suggesting that this approach may be effective in the context of bariatric surgery as well.
Where this research is happening
Winston-Salem, United States
- Wake Forest University — Winston-Salem, United States (Active)
Researchers
- Principal investigator: Beavers, Kristen Marie — Wake Forest University
- Study coordinator: Beavers, Kristen Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.