Using birth tissue products to treat pain after surgery without opioids
Birth Tissue Products for Non-opioid Treatment of Post-surgical Pain
This study is looking at how using natural products from human cells, like amniotic membrane and umbilical cord, can help manage pain after surgery without relying on opioids, and it’s for anyone interested in safer pain relief options.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10907034 on NIH RePORTER |
What this research studies
This research investigates the use of human cell and tissue products, such as amniotic membrane and umbilical cord, as a non-opioid treatment for post-surgical pain. The study aims to demonstrate the effectiveness and safety of these products by first testing them in animal models and then exploring their mechanisms of action on immune cells and sensory neurons. By targeting inflammation and promoting healing, the research seeks to provide a safer alternative to traditional opioid pain relief methods.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients undergoing surgical procedures who are at risk of experiencing significant post-surgical pain.
Not a fit: Patients who are not undergoing surgery or those who do not experience post-surgical pain may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a novel, safe treatment option for managing post-surgical pain without the risks associated with opioids.
How similar studies have performed: Other research has shown promise in using similar human tissue products for pain management, indicating potential for success in this approach.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Guan, Yun — Johns Hopkins University
- Study coordinator: Guan, Yun
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.