Using biomaterials to improve stem cell therapy for rotator cuff injuries
Biomaterials to enhance the efficacy of MSCs for rotator cuff repair
This study is looking at how special materials can help stem cells work better to heal rotator cuff tears, which could lead to faster recovery and less muscle loss after surgery for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgia Institute of Technology NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-11136240 on NIH RePORTER |
What this research studies
This research investigates how biomaterials can enhance the effectiveness of mesenchymal stem cells (MSCs) in repairing rotator cuff tears. The approach focuses on developing microparticle carriers that help retain these cells at the injury site and improve their regenerative capabilities. By examining the relationship between the properties of these biomaterials and the metabolic fitness of the MSCs, the research aims to optimize the healing process of the supraspinatus muscle after tendon repair. Patients may benefit from improved recovery outcomes and reduced muscle degeneration following surgery.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from rotator cuff tears, particularly those who may be facing surgery for repair.
Not a fit: Patients with rotator cuff injuries who are not candidates for surgical intervention may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for rotator cuff injuries, resulting in better recovery and less muscle atrophy.
How similar studies have performed: Previous research has shown promise in using biomaterials to enhance stem cell therapies, indicating potential for success in this novel approach.
Where this research is happening
Atlanta, United States
- Georgia Institute of Technology — Atlanta, United States (Active)
Researchers
- Principal investigator: Temenoff, Johnna S — Georgia Institute of Technology
- Study coordinator: Temenoff, Johnna S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.