Using biomarkers to personalize treatment for alcohol use disorder and PTSD
Leveraging biomarkers for personalized treatment of alcohol use disorder comorbid with PTSD
This study is looking at how certain biological markers can help customize treatments for people dealing with both alcohol use disorder and post-traumatic stress disorder, and it will test how well the medication topiramate works for them while considering their genetic factors.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11141372 on NIH RePORTER |
What this research studies
This research investigates how specific biological markers can help tailor treatments for individuals suffering from both alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD). The study will evaluate the effectiveness of topiramate, a medication that has shown promise in treating both conditions, through a double-blind clinical trial. Participants will be monitored for changes in their symptoms and overall well-being, with a focus on how genetic factors may influence treatment outcomes. By understanding the interplay between these disorders and their treatments, the research aims to improve therapeutic strategies for affected patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with both alcohol use disorder and moderate-to-severe post-traumatic stress disorder.
Not a fit: Patients who do not have a diagnosis of either alcohol use disorder or PTSD may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatment options for patients with both alcohol use disorder and PTSD.
How similar studies have performed: Previous research has shown promising results for using topiramate in treating alcohol use disorder and PTSD, indicating that this approach may be effective.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Marmar, Charles R. — New York University School of Medicine
- Study coordinator: Marmar, Charles R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.