Using biomarkers to personalize treatment for alcohol use disorder and PTSD
Official title: Leveraging biomarkers for personalized treatment of alcohol use disorder comorbid with PTSD
Funded at New York University School of Medicine · NIH-11141372 · Data updated 2026-11-12
This study is looking at how certain biological markers can help customize treatments for people dealing with both alcohol use disorder and post-traumatic stress disorder, and it will test how well the medication topiramate works for them while considering their genetic factors.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $254,250 |
| NIH project number | 3P01AA027057-05S1 |
| Project ID | NIH-11141372 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with both alcohol use disorder and moderate-to-severe post-traumatic stress disorder.
✕Less likely to help
Patients who do not have a diagnosis of either alcohol use disorder or PTSD may not benefit from this research.
What this research studies
This research investigates how specific biological markers can help tailor treatments for individuals suffering from both alcohol use disorder (AUD) and post-traumatic stress disorder (PTSD). The study will evaluate the effectiveness of topiramate, a medication that has shown promise in treating both conditions, through a double-blind clinical trial. Participants will be monitored for changes in their symptoms and overall well-being, with a focus on how genetic factors may influence treatment outcomes. By understanding the interplay between these disorders and their treatments, the research aims to improve therapeutic strategies for affected patients.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized treatment options for patients with both alcohol use disorder and PTSD.
How similar studies have gone: Previous research has shown promising results for using topiramate in treating alcohol use disorder and PTSD, indicating that this approach may be effective.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Marmar, Charles R. — New York University School of Medicine
- Study coordinator: Marmar, Charles R.
Related research
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Finding brain proteins linked to PTSD and alcohol use disorder
This study is looking at how certain proteins in the brain might be linked to PTSD and alcohol use problems in U.S. Veterans, with the hope of finding new treatments that can help those dealing with these challenges.
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Genetic links between PTSD and alcohol problems from adolescence to adulthood
This research looks at how genes and childhood trauma together relate to PTSD and alcohol problems from the teen years into adulthood.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.