Using biomarkers to improve kidney transplant outcomes
Assessment of Biomarker Guided CNI Substitution in Kidney Transplantation
This study is looking at how certain biological markers can help doctors tailor immunosuppressive treatments for kidney transplant patients to reduce the risk of complications like rejection, so they can provide more personalized care.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project ID | NIH-10886720 on NIH RePORTER |
What this research studies
This research investigates how specific biomarkers can guide the adjustment of immunosuppressive therapy in kidney transplant recipients. By focusing on the HLA-DR/DQ molecular mismatch score, the study aims to identify patients at risk for complications such as acute rejection. The approach includes a multicenter observational study combined with a randomized controlled trial to evaluate the effectiveness of personalized immunosuppression strategies. Patients will be monitored for their response to changes in treatment based on these biomarkers.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have received a kidney transplant and are experiencing complications related to their immunosuppressive therapy.
Not a fit: Patients who have not undergone kidney transplantation or those who are not experiencing issues with their current immunosuppressive regimen may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved kidney transplant outcomes and reduced side effects from immunosuppressive medications.
How similar studies have performed: Previous studies have shown promising results in using biomarkers for risk stratification in kidney transplantation, but this specific approach is novel and has not been extensively tested in prospective trials.
Where this research is happening
Los Angeles, United States
- Cedars-Sinai Medical Center — Los Angeles, United States (Active)
Researchers
- Principal investigator: Heeger, Peter Scott — Cedars-Sinai Medical Center
- Study coordinator: Heeger, Peter Scott
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.