Using biomarkers to choose the best antidepressant for treatment-resistant depression.

Who could benefit from this research

What this research studies

This research focuses on improving treatment for individuals with treatment-resistant depression (TRD) by using biomarkers to guide the selection of antidepressants. It aims to compare two effective treatments, ketamine and accelerated repetitive transcranial magnetic stimulation (rTMS), which can provide rapid relief from depressive symptoms. By understanding individual differences in how patients respond to these treatments, the research seeks to minimize the trial-and-error approach currently used by clinicians. The project will involve developing and testing a new method to match patients with the treatment that is most likely to be effective for them based on their unique neurobiological profiles.

Why it matters

Where this research is happening

• Weill Medical Coll of Cornell Univ
  New York, United States Active

Researchers

• Principal investigator: Liston, Conor M — Weill Medical Coll of Cornell Univ
• Study coordinator: Liston, Conor M

Related research

Other NIH-funded projects on the same topics.

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• Bioenergetic supplements for hard-to-treat depression and anxiety

  A grant test-beds the idea that nutrients like creatine and acetyl-L-carnitine could help people with treatment-resistant depression, anxiety, and cognitive problems.

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• Multi-site psilocybin trial for treatment-resistant depression in Veterans

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• Cell-free DNA as a biomarker for electroconvulsive therapy in treatment-resistant depression

  A study with people who have treatment-resistant depression will explore whether fragments of DNA circulating in blood can reflect how well electroconvulsive therapy works.

  NIH research University of California Los Angeles · Los Angeles, United States · NIH-11289221

About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.