Using biologic medications to improve treatment for chronic rhinosinusitis with nasal polyps
SMART Use of Biologics in Chronic Rhinosinusitis with Nasal Polyposis
['FUNDING_U01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11084929
This study is looking at how to make treatments for chronic rhinosinusitis with nasal polyps work better for you by figuring out which biologic medication might be the best fit based on your individual needs, so you can feel better without going through a lot of trial and error.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11084929 on ClinicalTrials.gov |
What this research studies
This research investigates how different biologic medications can be used more effectively to treat chronic rhinosinusitis with nasal polyps (CRSwNP). It aims to identify which biologic is best suited for individual patients by comparing clinical outcomes and exploring the use of biomarkers to predict responses. The study addresses the current challenge where many patients do not respond to standard treatments, leading to a trial-and-error approach that can be costly and ineffective. By focusing on personalized treatment strategies, the research seeks to enhance patient care and quality of life.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with chronic rhinosinusitis with nasal polyps, particularly those who have not responded well to existing treatments.
Not a fit: Patients with chronic rhinosinusitis who do not have nasal polyps or those whose condition is not related to the Type 2 endotype may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients suffering from chronic rhinosinusitis with nasal polyps.
How similar studies have performed: Other research has shown promise in using biologics for treating chronic rhinosinusitis, but this approach of personalized treatment based on biomarkers is relatively novel.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SMITH, TIMOTHY L — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: SMITH, TIMOTHY L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.