Using biologic medications to improve treatment for chronic rhinosinusitis with nasal polyps
Official title: SMART Use of Biologics in Chronic Rhinosinusitis with Nasal Polyposis
Funded at Oregon Health & Science University · NIH-11084929 · Data updated 2026-11-12
This study is looking at how to make treatments for chronic rhinosinusitis with nasal polyps work better for you by figuring out which biologic medication might be the best fit based on your individual needs, so you can feel better without going through a lot of trial and error.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oregon Health & Science University NIH-funded |
| Lab location | 1 site (Portland, United States) |
| Project start | April 22, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $1,498,642 |
| NIH project number | 1U01AI181696-01A1 |
| Project ID | NIH-11084929 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic rhinosinusitis with nasal polyps, particularly those who have not responded well to existing treatments.
✕Less likely to help
Patients with chronic rhinosinusitis who do not have nasal polyps or those whose condition is not related to the Type 2 endotype may not benefit from this research.
What this research studies
This research investigates how different biologic medications can be used more effectively to treat chronic rhinosinusitis with nasal polyps (CRSwNP). It aims to identify which biologic is best suited for individual patients by comparing clinical outcomes and exploring the use of biomarkers to predict responses. The study addresses the current challenge where many patients do not respond to standard treatments, leading to a trial-and-error approach that can be costly and ineffective. By focusing on personalized treatment strategies, the research seeks to enhance patient care and quality of life.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for patients suffering from chronic rhinosinusitis with nasal polyps.
How similar studies have gone: Other research has shown promise in using biologics for treating chronic rhinosinusitis, but this approach of personalized treatment based on biomarkers is relatively novel.
Where this research is happening
-
Oregon Health & Science University
Portland, United States Active
Researchers
- Principal investigator: Smith, Timothy L — Oregon Health & Science University
- Study coordinator: Smith, Timothy L
Related research
Other NIH-funded projects on the same topics.
-
Understanding how a protein affects nerve cell movement in Alzheimer's disease
This study is looking at how a protein called APP affects the growth and movement of nerve cells, which is important for understanding Alzheimer's disease, and it aims to find out how problems with this protein might lead to nerve cell damage.
-
Understanding how the bone marrow environment drives AML resistance
A large NIH-funded project at Oregon Health & Science University is studying how the body’s own cell surroundings help acute myeloid leukemia become resistant to treatment, with potential paths to better therapies for patients.
-
Improving Safety at Work with a Low-Resource mHealth Program in Malaysia (and beyond)
A low-cost mobile health program to improve safety culture in Malaysian workplaces, with plans to adapt the approach for U.S. workers in high-risk industries.
-
Oregon Healthy Workplace Initiative for Better Health
A multi-site effort aims to improve the health and safety of workers by coordinating research, tools, and interventions across workplaces.
-
Understanding how AML cells become resistant to therapy over time
This project looks at why acute myeloid leukemia stops responding to treatment and how to design better drug combinations to prevent relapse.
-
Mechanisms and Countermeasures for Ultra-Potent Synthetic Opioid Overdose
A small, focused NIH grant aims to understand why ultra-potent synthetic opioids cause severe overdose and to explore potential countermeasures to keep people safe.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.