Using biodegradable scaffolds with stem cells to improve vascular access for dialysis patients
Biodegradable Radiopaque Polymeric Scaffolds Loaded with Mesenchymal Stem Cells for Image-Guided Arteriovenous Fistula Maturation and Long-Term Patency
This study is looking at a new way to help improve the success of arteriovenous fistulas (AVFs) for people on hemodialysis by using special materials that can help reduce inflammation and make it easier for doctors to see how well the AVF is working.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Tx Md Anderson Can Ctr NIH-funded |
| Lab location | 1 site (Houston, United States) |
| Project ID | NIH-11054662 on NIH RePORTER |
What this research studies
This research focuses on enhancing the maturation and long-term success of arteriovenous fistulas (AVFs), which are crucial for patients undergoing hemodialysis. The approach involves developing biodegradable polymeric scaffolds that can be wrapped around the AVF, loaded with mesenchymal stem cells to reduce inflammation, and equipped with imaging agents for better diagnosis. The safety and effectiveness of these scaffolds will be tested in animal models, aiming to address common complications associated with AVF failure. By improving AVF maturation, this research seeks to reduce morbidity and mortality in patients with end-stage renal disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients with end-stage renal disease who require hemodialysis and are at risk of arteriovenous fistula failure.
Not a fit: Patients who are not undergoing hemodialysis or do not have chronic kidney disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could significantly improve the success rates of vascular access for dialysis, leading to better patient outcomes and quality of life.
How similar studies have performed: While the use of biodegradable scaffolds and stem cells is a novel approach, similar strategies in vascular access have shown promise in preliminary studies.
Where this research is happening
Houston, United States
- University of Tx Md Anderson Can Ctr — Houston, United States (Active)
Researchers
- Principal investigator: Melancon, Marites Pasuelo — University of Tx Md Anderson Can Ctr
- Study coordinator: Melancon, Marites Pasuelo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.