Using beta blockers to prevent bone loss in postmenopausal women
Beta1-selective blockade for prevention of postmenopausal bone loss: A randomized controlled trial
This study is looking at whether a heart medication called beta1-selective blockers can help prevent bone loss and fractures in postmenopausal women, and if you join, you might receive either the medication or a placebo to see how it affects your bone health over two years.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11030853 on NIH RePORTER |
What this research studies
This research investigates the use of beta1-selective blockers, which are typically used for heart conditions, to prevent osteoporosis in postmenopausal women. The study aims to determine if these medications can safely improve bone density and reduce the risk of fractures by targeting the sympathetic nervous system's role in bone metabolism. Participants will be randomly assigned to receive either the medication or a placebo over a two-year period, allowing researchers to compare the effects on bone health. This approach seeks to provide a low-risk alternative to existing osteoporosis treatments that often have serious side effects.
Who could benefit from this research
Good fit: Ideal candidates for this research are postmenopausal women aged 65 and older who are at risk for osteoporosis.
Not a fit: Patients who are not postmenopausal or those who have already developed severe osteoporosis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could offer a new, safer method for preventing osteoporosis in postmenopausal women, potentially reducing fracture rates and healthcare costs.
How similar studies have performed: Previous studies have shown promising results using beta blockers for bone health, indicating that this approach may be effective.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Khosla, Sundeep — Mayo Clinic Rochester
- Study coordinator: Khosla, Sundeep
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.