NIH-funded research R01 grant

Using at-home neurostimulation to reduce pain in patients with end-stage kidney disease on dialysis

Official title: Delivery of an At-Home Nonpharmacologic Intervention (Transcranial Neurostimulation) to Mitigate Pain in Patients with End Stage Kidney Disease Receiving Hemodialysis

Funded at Weill Medical Coll of Cornell Univ · NIH-10991001 · Data updated 2026-11-12

This study is looking at a new way to help people with end-stage kidney disease manage their pain at home during hemodialysis using a gentle electrical stimulation method, which could reduce the need for strong pain medications.

More Kidney Disease research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionWeill Medical Coll of Cornell Univ
NIH-funded
Lab location1 site (New York, United States)
Project startDecember 1, 2021
Project endNovember 30, 2025
Funding year2025
Award (this year)$517,198
NIH project number5R01DK131050-04
Project IDNIH-10991001 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are adults aged 21 and older who are receiving hemodialysis for end-stage kidney disease and experience chronic pain.

Less likely to help

Patients who are not undergoing hemodialysis or those with acute pain conditions unrelated to chronic kidney disease may not benefit from this research.

What this research studies

This research investigates the use of transcranial direct current stimulation (tDCS), a non-invasive therapy, to help manage pain in patients with end-stage kidney disease who are undergoing hemodialysis. The approach aims to provide an at-home intervention that minimizes reliance on opioid medications, which can have significant side effects. By focusing on a diverse patient population, particularly racial and ethnic minorities, the study seeks to rigorously evaluate the safety and effectiveness of this novel pain management technique. Patients will receive stimulation sessions at home, allowing for greater accessibility and convenience.

Why it matters

Potential benefit: If successful, this research could significantly improve pain management for patients with end-stage kidney disease, enhancing their quality of life and reducing the need for opioid medications.

How similar studies have gone: Previous studies have shown promise with transcranial direct current stimulation in managing chronic pain, but this specific application in end-stage kidney disease is relatively novel.

Where this research is happening

  • Weill Medical Coll of Cornell Univ
    New York, United States
    Active

Researchers

  • Principal investigator: Reid, Manney Carrington — Weill Medical Coll of Cornell Univ
  • Study coordinator: Reid, Manney Carrington

Related research

Other NIH-funded projects on the same topics.

  • Fistula versus graft for hemodialysis access in older adults

    This study compares two types of surgical dialysis access—fistulas and grafts—to find which is better for adults aged 65 and older who are using a catheter for hemodialysis.

    NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11178427

  • Comparing two types of vascular access for older adults on hemodialysis

    This study is looking at how well two types of surgeries for getting blood access work for older adults with severe kidney disease who need dialysis, to see which one helps them feel better and be happier with their treatment.

    NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-10912828

  • How dialysis facility growth affects care for people with end-stage kidney disease

    New research will examine whether the spread of dialysis centers and new treatment technologies benefit patients with end-stage kidney disease, and whether benefits reach all communities.

    NIH research National Bureau of Economic Research · Cambridge, United States · NIH-11434364

  • Hospital-to-SNF Transitions for Kidney Failure Patients

    Aimed at improving how patients with end-stage kidney disease move from hospital to skilled nursing facilities to reduce readmissions.

    NIH research Weill Medical Coll of Cornell Univ · New York, United States · NIH-11416733

  • Medically tailored meals for children with kidney failure

    A study compares different ways to give tailored meals to kids with end-stage kidney disease to see what works best for families and health.

    NIH research Baylor College of Medicine · Houston, United States · NIH-11415911

  • Telehealth for rural patients with end-stage kidney disease

    A doctor-researcher at a major university is studying how telehealth can help people with advanced kidney disease in rural areas access care and stay on track for transplantation.

    NIH research University of Texas at Austin · Austin, United States · NIH-11415422

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.