Using artificial microRNA to fight glioblastoma resistance to treatment
Harnessing Artificial MicroRNA Clusters Against Glioblastoma Epigenetic Plasticity and Resistance to Therapy
This study is looking at how certain proteins help glioblastoma, a tough type of brain cancer, resist treatments like chemotherapy and radiation, and it aims to find a new way to make these tumors easier to treat by reintroducing specific microRNAs that can weaken their defenses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10543193 on NIH RePORTER |
What this research studies
This research focuses on glioblastoma, a highly aggressive brain cancer that has shown little improvement in survival rates over the years. The project aims to understand how certain proteins help glioblastoma cells resist therapies like chemotherapy and radiation. By investigating the role of specific microRNAs that are lost in glioblastoma, the researchers hope to develop a new treatment strategy that can make these tumors more susceptible to existing therapies. This approach involves reintroducing these microRNAs to inhibit the protective mechanisms of the tumor cells.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with glioblastoma who are currently undergoing or have previously undergone standard therapies.
Not a fit: Patients with other types of brain tumors or those who are not diagnosed with glioblastoma may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for glioblastoma, potentially improving survival rates for patients.
How similar studies have performed: Previous research has shown promise in using microRNA therapies for cancer treatment, indicating potential success for this novel approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Peruzzi, Pier Paolo — Brigham and Women's Hospital
- Study coordinator: Peruzzi, Pier Paolo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.