Using approved medicines to break up harmful protein clumps in Alzheimer's
Repurposing FDA-approved drugs to disrupt tau- and amyloid-associated protein-protein interactions in Alzheimer's disease aggregates
Testing whether already-approved drugs can disrupt sticky tau and amyloid protein clumps that form in people with Alzheimer's disease.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Central Arkansas Veterans Hlthcare Sys NIH-funded |
| Lab location | 1 site (North Little Rock, United States) |
| Project ID | NIH-11206875 on NIH RePORTER |
What this research studies
Researchers map how proteins stick together in Alzheimer’s brain tissue to find the exact contact points that hold toxic clumps together. They use computer screening to find FDA-approved drugs that can fit into those protein interfaces and block them. Promising hits are tested in human cells and simple animal models, and the top candidates will be tried next in mice. The goal is to move faster toward treatments because these drugs are already approved for other uses.
Who could benefit from this research
Good fit: People with Alzheimer’s disease, especially those in earlier stages or with evidence of tau and amyloid pathology, would be the most likely candidates for future trials based on this work.
Not a fit: People with non-amyloid/tau causes of dementia or those in very advanced, end-stage Alzheimer’s are unlikely to benefit from these anti-aggregation approaches.
Why it matters
Potential benefit: If successful, this could reduce or clear harmful protein aggregates and slow the progression of memory and thinking problems in Alzheimer's patients.
How similar studies have performed: Laboratory and animal studies of drug repurposing and anti-aggregation approaches have shown promise, but clinical success in people has been limited so far.
Where this research is happening
North Little Rock, United States
- Central Arkansas Veterans Hlthcare Sys — North Little Rock, United States (Active)
Researchers
- Principal investigator: Shmookler Reis, Robert Joseph — Central Arkansas Veterans Hlthcare Sys
- Study coordinator: Shmookler Reis, Robert Joseph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.