Using antioxidants to improve blood vessel health in older adults
Mitochondrial-targeted antioxidant supplementation for improving age-related vascular dysfunction in humans
This study is looking at whether taking a supplement called MitoQ can help improve blood vessel health in older adults who are at risk for heart problems, by making their blood vessels work better and be less stiff.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado NIH-funded |
| Lab location | 1 site (Boulder, UNITED STATES) |
| Project ID | NIH-11004136 on NIH RePORTER |
What this research studies
This research investigates the effects of a specific antioxidant, MitoQ, on improving blood vessel function in older adults who are at risk for cardiovascular diseases. The study focuses on how MitoQ can reduce harmful molecules produced by mitochondria that contribute to vascular dysfunction and stiffness. Participants will receive oral MitoQ supplementation, and the research will assess changes in blood vessel dilation and stiffness over time. The goal is to find a new way to enhance vascular health and reduce the risk of heart disease as people age.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults aged 60 and above who are experiencing age-related vascular dysfunction.
Not a fit: Patients under 60 years old or those without signs of vascular dysfunction may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that significantly improve vascular health and reduce cardiovascular disease risk in older adults.
How similar studies have performed: Previous studies have shown promising results with MitoQ in animal models, and initial pilot studies in older adults suggest potential benefits, indicating a novel approach to addressing vascular health.
Where this research is happening
Boulder, UNITED STATES
- University of Colorado — Boulder, United States (Active)
Researchers
- Principal investigator: Seals, Douglas R — University of Colorado
- Study coordinator: Seals, Douglas R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.