Using antibody analysis to prevent and detect tuberculosis in children with HIV
Official title: Leveraging antibody-omics to prevent and detect TB in children affected by HIV
Funded at Emory University · NIH-11189943 · Data updated 2026-11-12
This study is looking for better ways to spot and prevent tuberculosis (TB) in children with HIV by checking their blood for special antibodies that might show how their immune system is fighting the disease, with the hope of improving diagnosis and health for these kids.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | May 22, 2025 |
| Project end | April 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $209,750 |
| NIH project number | 1R21AI192086-01 |
| Project ID | NIH-11189943 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include children under 11 years old who are either affected by HIV or have been exposed to it.
✕Less likely to help
Patients who are not children or those without any connection to HIV or tuberculosis may not benefit from this research.
What this research studies
This research investigates new ways to diagnose and prevent tuberculosis (TB) in children who are affected by HIV. It focuses on understanding how the immune system responds to TB by analyzing specific antibodies in blood samples from children in various countries. The study aims to identify unique antibody features that could indicate protection against TB and help in diagnosing active infections. By leveraging existing clinical data and samples, the research seeks to improve current diagnostic methods and ultimately enhance public health outcomes for vulnerable children.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and preventive strategies for tuberculosis in children living with HIV.
How similar studies have gone: Previous research has shown promise in using antibody profiling for TB diagnosis, suggesting that this approach could yield significant insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Cranmer, Lisa M — Emory University
- Study coordinator: Cranmer, Lisa M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.