Using antibodies to target immune cells in nonhuman primates for disease research
Nonhuman Primate Antibody Resource for Immune Cell Depletion
This study is all about creating special antibodies that help scientists learn more about diseases and test new treatments in nonhuman primates, which are important for understanding how our immune system works and improving vaccines.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of Massachusetts Med Sch Worcester NIH-funded |
| Lab location | 1 site (Worcester, United States) |
| Project ID | NIH-10935284 on NIH RePORTER |
What this research studies
This research focuses on developing and providing immune cell-depleting antibodies that target specific cell types in nonhuman primates (NHPs). These antibodies are crucial for studying diseases and testing new therapies and vaccines that cannot be evaluated in smaller animal models. By depleting certain immune cells, researchers can better understand disease mechanisms and improve vaccine design. The project has been supported for over two decades and has fulfilled numerous requests from scientists for these vital research reagents.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research are individuals involved in preclinical studies of vaccines and therapies that utilize nonhuman primate models.
Not a fit: Patients who are not involved in research or do not have access to therapies being tested in nonhuman primates may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective vaccines and therapies for infectious diseases.
How similar studies have performed: Previous research has shown success in using immune cell-depleting antibodies in nonhuman primate models, indicating a strong foundation for this approach.
Where this research is happening
Worcester, United States
- Univ of Massachusetts Med Sch Worcester — Worcester, United States (Active)
Researchers
- Principal investigator: Magnani, Diogo — Univ of Massachusetts Med Sch Worcester
- Study coordinator: Magnani, Diogo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.