Using antibodies to control HIV-1 infection.
Immunologic control of HIV-1 through combination bNAbs and biologics.
This study is looking at how special antibodies can help people with HIV control the virus better and possibly stay healthy without needing daily medication, by giving these antibodies to HIV-infected individuals and seeing how they improve their immune response over time.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10754874 on NIH RePORTER |
What this research studies
This research investigates the use of broadly neutralizing antibodies (bNAbs) to control HIV-1 infection in patients. It aims to explore how these antibodies can enhance the immune response and potentially lead to long-term remission from the virus without the need for ongoing antiretroviral therapy. The approach involves administering specific bNAbs, 3BNC117 and 10-1074, to HIV-infected individuals to see if they can maintain viral suppression and improve immune function. The study will monitor the effects of these treatments over time to assess their efficacy in controlling the virus.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults living with HIV who have not developed resistance to the specific antibodies being tested.
Not a fit: Patients who are not infected with HIV or those with resistant strains of the virus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options that allow HIV patients to maintain viral suppression without continuous medication.
How similar studies have performed: Previous studies have shown promising results with similar approaches using bNAbs in animal models and early human trials.
Where this research is happening
New York, United States
- Rockefeller University — New York, United States (Active)
Researchers
- Principal investigator: Caskey, Marina — Rockefeller University
- Study coordinator: Caskey, Marina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.