Using antibiotics to reduce cesarean delivery complications in obese first-time mothers.
Official title: Antibiotic Prophylaxis to Prevent Obesity-related Induction Complications in Nulliparae at Term (APPOINT 2.0)
Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10980684 · Data updated 2026-11-12
This study is looking at whether giving antibiotics during labor can help reduce the chances of first-time moms who are obese needing a cesarean delivery, and it's designed for those expecting their first baby.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Oklahoma Hlth Sciences Ctr NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project start | September 17, 2024 |
| Project end | August 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $677,083 |
| NIH project number | 1R01HD113755-01A1 |
| Project ID | NIH-10980684 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are nulliparous women with obesity who are undergoing labor induction at term.
✕Less likely to help
Patients who are not nulliparous or who do not have obesity may not benefit from this research.
What this research studies
This research investigates whether administering prophylactic antibiotics during labor can lower the rate of cesarean deliveries in obese first-time mothers. The study builds on previous findings that suggested a reduction in cesarean rates with antibiotic use. By conducting a large multi-center trial, the researchers aim to confirm these results and provide a more definitive answer. The approach involves comparing outcomes between women receiving antibiotics and those receiving a placebo during labor induction.
Why it matters
Potential benefit: If successful, this research could lead to a significant reduction in cesarean delivery rates and associated complications for obese first-time mothers.
How similar studies have gone: Previous pilot studies have shown promising results with similar antibiotic prophylaxis approaches, indicating potential for success in this larger trial.
Where this research is happening
-
University of Oklahoma Hlth Sciences Ctr
Oklahoma City, United States Active
Researchers
- Principal investigator: Pierce, Stephanie — University of Oklahoma Hlth Sciences Ctr
- Study coordinator: Pierce, Stephanie
Related research
Other NIH-funded projects on the same topics.
-
Understanding how knee pain and knee obesity and muscle loss affect knee osteoarthritis
This project looks at how knee swelling, excess knee fat, and muscle loss relate to pain and structural changes in knee osteoarthritis in adults.
-
Understanding how maternal and infant sleep and daily rhythms influence early appetite and obesity risk
This project explores how infant sleep, circadian rhythms, and maternal-infant timing relate to early appetite patterns and the risk of obesity in the first year of life.
-
GLP-1 receptor agonists as immune targets to treat asthma in lean and obese adults
Aims to understand how GLP-1R‑agonist diabetes medicines may directly calm immune cells to reduce asthma in adults who are lean or obese.
-
Understanding how where you live and personal factors during pregnancy affect a child’s risk for obesity and metabolic problems
This project looks at how neighborhood conditions and individual factors during pregnancy may influence a child’s risk of obesity and metabolic health as they grow.
-
Multicomponent lifestyle program to curb obesity and cardiometabolic risk in Samoan children
A locally designed lifestyle program aimed at preventing obesity and heart-disease risk in Samoan kids, with a focus on daily routines, healthy eating, sleep, and family support.
-
Game-based mobile app to help pregnant women with overweight/obesity manage weight in Nepal
A new app designed for pregnant women in Nepal with overweight or obesity to help manage weight gain during pregnancy and reduce weight retention after birth.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.