Using antibiotics to reduce cesarean delivery complications in obese first-time mothers.
Antibiotic Prophylaxis to Prevent Obesity-related Induction Complications in Nulliparae at Term (APPOINT 2.0)
['FUNDING_R01'] · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · NIH-10980684
This study is looking at whether giving antibiotics during labor can help reduce the chances of first-time moms who are obese needing a cesarean delivery, and it's designed for those expecting their first baby.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR (nih funded) |
| Locations | 1 site (OKLAHOMA CITY, UNITED STATES) |
| Trial ID | NIH-10980684 on ClinicalTrials.gov |
What this research studies
This research investigates whether administering prophylactic antibiotics during labor can lower the rate of cesarean deliveries in obese first-time mothers. The study builds on previous findings that suggested a reduction in cesarean rates with antibiotic use. By conducting a large multi-center trial, the researchers aim to confirm these results and provide a more definitive answer. The approach involves comparing outcomes between women receiving antibiotics and those receiving a placebo during labor induction.
Who could benefit from this research
Good fit: Ideal candidates for this research are nulliparous women with obesity who are undergoing labor induction at term.
Not a fit: Patients who are not nulliparous or who do not have obesity may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to a significant reduction in cesarean delivery rates and associated complications for obese first-time mothers.
How similar studies have performed: Previous pilot studies have shown promising results with similar antibiotic prophylaxis approaches, indicating potential for success in this larger trial.
Where this research is happening
OKLAHOMA CITY, UNITED STATES
- UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR — OKLAHOMA CITY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: PIERCE, STEPHANIE — UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR
- Study coordinator: PIERCE, STEPHANIE
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.