NIH-funded research R01 grant

Using antibiotics to reduce cesarean delivery complications in obese first-time mothers.

Official title: Antibiotic Prophylaxis to Prevent Obesity-related Induction Complications in Nulliparae at Term (APPOINT 2.0)

Funded at University of Oklahoma Hlth Sciences Ctr · NIH-10980684 · Data updated 2026-11-12

This study is looking at whether giving antibiotics during labor can help reduce the chances of first-time moms who are obese needing a cesarean delivery, and it's designed for those expecting their first baby.

More Obesity research and trials

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUniversity of Oklahoma Hlth Sciences Ctr
NIH-funded
Lab location1 site (Oklahoma City, United States)
Project startSeptember 17, 2024
Project endAugust 31, 2029
Funding year2024
Award (this year)$677,083
NIH project number1R01HD113755-01A1
Project IDNIH-10980684 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are nulliparous women with obesity who are undergoing labor induction at term.

Less likely to help

Patients who are not nulliparous or who do not have obesity may not benefit from this research.

What this research studies

This research investigates whether administering prophylactic antibiotics during labor can lower the rate of cesarean deliveries in obese first-time mothers. The study builds on previous findings that suggested a reduction in cesarean rates with antibiotic use. By conducting a large multi-center trial, the researchers aim to confirm these results and provide a more definitive answer. The approach involves comparing outcomes between women receiving antibiotics and those receiving a placebo during labor induction.

Why it matters

Potential benefit: If successful, this research could lead to a significant reduction in cesarean delivery rates and associated complications for obese first-time mothers.

How similar studies have gone: Previous pilot studies have shown promising results with similar antibiotic prophylaxis approaches, indicating potential for success in this larger trial.

Where this research is happening

  • University of Oklahoma Hlth Sciences Ctr
    Oklahoma City, United States
    Active

Researchers

  • Principal investigator: Pierce, Stephanie — University of Oklahoma Hlth Sciences Ctr
  • Study coordinator: Pierce, Stephanie

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.