Using antibiotic combinations to fight resistant bacterial infections
Exploitation of multiple heteroresistance for effective antibiotic combination therapy
This study is looking at how to use different combinations of antibiotics to better treat tough infections caused by resistant bacteria, like Acinetobacter baumannii, so that patients with serious infections can get more effective and personalized care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project ID | NIH-10861934 on NIH RePORTER |
What this research studies
This research investigates how to effectively use combinations of antibiotics to treat infections caused by resistant bacteria, particularly focusing on Acinetobacter baumannii. The approach aims to understand the mechanisms behind antibiotic resistance and how certain combinations can be tailored to overcome this resistance. By studying the unique properties of bacterial isolates, the research seeks to develop personalized treatment strategies that can effectively target even the most resistant strains. This could lead to more effective therapies for patients suffering from severe bacterial infections.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients suffering from infections caused by antibiotic-resistant bacteria, particularly those infected with Acinetobacter baumannii.
Not a fit: Patients with infections caused by bacteria that are not resistant to antibiotics may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment options for patients with antibiotic-resistant infections, potentially saving lives.
How similar studies have performed: Other research has shown promise in using combination therapies to combat antibiotic resistance, indicating that this approach could be effective.
Where this research is happening
Atlanta, United States
- Emory University — Atlanta, United States (Active)
Researchers
- Principal investigator: Weiss, David S — Emory University
- Study coordinator: Weiss, David S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.