Using anti-seizure medications to prevent complications after traumatic brain injuries in older adults
Official title: Traumatic Brain Injury Anti-Seizure Prophylaxis in the Medicare Program
Funded at Massachusetts General Hospital · NIH-11127468 · Data updated 2026-11-12
This study is looking at how anti-seizure medications can help older adults, especially those with Alzheimer’s or related conditions, who have had a traumatic brain injury, while also keeping an eye on any serious side effects to make sure they get the best care possible.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $746,174 |
| NIH project number | 5R01AG082693-03 |
| Project ID | NIH-11127468 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include older adults aged 65 and above who have suffered a traumatic brain injury, especially those with Alzheimer’s Disease or related dementias.
✕Less likely to help
Patients who are younger than 65 years old or those who have not experienced a traumatic brain injury may not benefit from this research.
What this research studies
This research investigates the use of anti-seizure medications (ASM) for older adults who have experienced a traumatic brain injury (TBI). It focuses on understanding the balance between the potential life-saving benefits of these medications and their serious side effects, particularly in older adults with Alzheimer’s Disease and Related Dementias (ADRD). By analyzing Medicare claims data and linking it with other health records, the research aims to improve how TBI severity is classified and to provide better guidance on ASM use in this vulnerable population. The goal is to enhance patient safety and treatment outcomes for older adults recovering from TBIs.
Why it matters
Potential benefit: If successful, this research could lead to safer and more effective treatment protocols for older adults at risk of seizures after a traumatic brain injury.
How similar studies have gone: While there is limited existing research on this specific approach, the use of linked data sources for improving treatment decisions in older adults has shown promise in other studies.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Moura, Lidia Maria Veras Rocha de — Massachusetts General Hospital
- Study coordinator: Moura, Lidia Maria Veras Rocha de
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.