Using AI to predict how SARS-CoV-2 variants evolve in people with HIV
A Phylodynamic Artificial Intelligence framework to predict evolution of SARS-CoV-2 variants of concern in Immunocompromised persons with HIV (PhAI-CoV)
This study is looking at how the COVID-19 virus changes in people with weakened immune systems from HIV, using smart technology to track these changes and help find better ways to protect their health.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Florida NIH-funded |
| Lab location | 1 site (Gainesville, United States) |
| Project ID | NIH-10857191 on NIH RePORTER |
What this research studies
This research aims to understand how the SARS-CoV-2 virus evolves within individuals who are immunocompromised due to HIV. By developing an artificial intelligence framework, the project will analyze the genetic changes of the virus in these patients, particularly focusing on the emergence of variants that may evade the immune response. The study will involve collecting and analyzing viral genomes from infected individuals to predict future variants and their potential impact on health. This approach could lead to better management strategies for COVID-19 in vulnerable populations.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who have contracted SARS-CoV-2.
Not a fit: Patients who are not immunocompromised or those who have not contracted SARS-CoV-2 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved predictions of COVID-19 variant emergence, enhancing treatment and prevention strategies for immunocompromised patients.
How similar studies have performed: Previous research has shown that AI can effectively analyze viral evolution, suggesting that this approach may yield valuable insights.
Where this research is happening
Gainesville, United States
- University of Florida — Gainesville, United States (Active)
Researchers
- Principal investigator: Salemi, Marco — University of Florida
- Study coordinator: Salemi, Marco
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.